Some of the things that should guide you when first looking at this target are:

• The ether functionalities. You know several ways of making these.
• The 1,2-dioxygenation pattern. Looking at relationships between functional groups can help you find the most efficient routes.
• The connectivity of carbon atoms. Just by inspection, you can see that given your "6 carbons or less" requirement, your synthesis will have to include at least one carbon-carbon bond forming step.

Retrosynthetic Analysis

Here are two possible initial disconnections...

Think about why the above method isn't a good approach and then check the anwswer.

Now let's look at method b.

Continue.

back

main

continue